Isotretinoin in Pregnancy

Case

I used isotretinoin 20 mg daily, first month of pregnancy.

Report

Isotretinoin, commonly known by brand names such as Accutane, is a retinoid medication primarily used to treat severe cystic acne. It is a derivative of vitamin A and works by reducing sebaceous gland size and sebum production, as well as normalizing keratinization. While highly effective for acne treatment, isotretinoin is known for its significant side effects and teratogenic potential, which necessitates strict regulations regarding its use.

Isotretinoin is a well-documented human teratogen, meaning it can cause birth defects if taken during pregnancy. Exposure to isotretinoin during the first month of pregnancy is particularly concerning due to its association with severe congenital anomalies. These can include craniofacial, cardiac, thymic, and central nervous system defects, among others. There is also an increased risk of spontaneous abortion and premature birth. The teratogenic effects are so significant that women of childbearing potential are required to use effective contraception and undergo regular pregnancy testing during treatment with isotretinoin.

In summary, the use of isotretinoin during the first month of pregnancy poses a high risk of severe birth defects and other pregnancy complications. It is crucial to contact a healthcare provider immediately to discuss potential implications and necessary steps.

[This report] offers a AI assisted literature review service on the potential teratogenic effects of medications. The information provided is for general reference only and we do not accept responsibility for its accuracy or completeness. By using this service, users agree to these terms. For more detailed information and personalized advice, please consult a healthcare professional.