Metformin in Pregnancy

Case

I used metformin 1000 mg daily, first two months of pregnancy.

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Metformin is an oral medication commonly used to manage type 2 diabetes mellitus and polycystic ovary syndrome (PCOS). It belongs to a class of drugs known as biguanides, which work by increasing insulin sensitivity, decreasing hepatic glucose production, and reducing intestinal glucose absorption. It also helps lower serum insulin and androgen levels, which can be beneficial for women with PCOS.

Regarding teratogenicity, studies have shown that metformin does not increase the risk of birth defects when used during human pregnancy, including the first trimester. This is particularly relevant for women with PCOS, as metformin use has been associated with a decreased rate of spontaneous abortions and gestational diabetes. In several studies, continuation of metformin during the first trimester did not adversely affect birth weight or lead to postnatal complications. Additionally, infants born to mothers who used metformin throughout pregnancy have shown normal motor and social development in the first 18 months of life. However, some studies have noted an association between metformin use and preeclampsia or perinatal mortality when compared to other oral hypoglycemics or insulin, but these findings are not consistent across all studies.

In summary, the use of metformin at 1000 mg daily during the first two months of pregnancy is generally considered safe and does not appear to increase the risk of teratogenic effects. However, it is important to consult with a healthcare provider for personalized advice and monitoring.

[This report] offers a AI assisted literature review service on the potential teratogenic effects of medications. The information provided is for general reference only and we do not accept responsibility for its accuracy or completeness. By using this service, users agree to these terms. For more detailed information and personalized advice, please consult a healthcare professional.